Platelet life span in hemodialysis patients
نویسندگان
چکیده
منابع مشابه
Proteasome regulates platelet life span 1 Regulatory role of proteasome in determination of platelet life span*
Background: The molecular players regulating platelet life span are largely unexplored. Results: Proteasome inhibition induced apoptotic changes in platelets associated with rise in active Bax and significant drop in platelet life span. Conclusion: Proteasome plays crucial role in delimiting platelet life span through constitutive elimination of the conformationally active Bax. Significance: Th...
متن کاملCorrelation between Inflammatory Biomarkers and Red Blood Cell Life Span in Chronic Hemodialysis Patients.
BACKGROUND AND OBJECTIVES The pathogenesis of anemia in hemodialysis (HD) patients is dependent on multiple factors, with decreased red blood cell life span (RBCLS) being a significant contributor. Although the impact of reduced RBCLS on anemia is recognized, it is still a subject that is not well researched. The objective of this study was to investigate the relationship between RBCLS and infl...
متن کاملPlatelet life span in normal, splenectomized and hypersplenic rats.
destruction, and the increased platelet level following splenectomy might be due to a decreased destruction of platelets. Likewise, the decreased level in hypersplenism might be due to an increased destruction. One approach to this problem is to label platelets in vitro, and then study their localization in the normal animal. The spleen contains a considerable amount of the label in such experi...
متن کاملPlatelet Life Span in Normal, Splenectomized and Hyperspienic Rats
destruction, and the increased platelet level following splenectomy might be due to a decreased destruction of platelets. Likewise, the decreased level in hypersplenism might be due to an increased destruction. One approach to this problem is to label platelets in vitro, and then study their localization in the normal animal. The spleen contains a considerable amount of the label in such experi...
متن کاملRegulatory role of proteasome in determination of platelet life span.
Limit of platelet life span (8-10 days) is determined by the activity of a putative "internal clock" composed of Bcl-2 family proteins, whereas the role of other molecular players in this process remains obscure. Here, we sought to establish a central role of proteasome in platelet life span regulation. Administration of mice with inhibitors of proteasome peptidase activity induced significant ...
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ژورنال
عنوان ژورنال: Journal of Japanese Society for Dialysis Therapy
سال: 1986
ISSN: 0911-5889,1884-6211
DOI: 10.4009/jsdt1985.19.655